- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.
Thioredoxin-Caspase 3 interaction disruptor; apotosis inducer
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| web metadata keyword.default | 4,6-Dichloro-N-(4′-fluoro-[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine,CAS 2138882-71-8 KEA1-97,KEA1-97 Thioredoxin-Caspase 3 interaction disruptor,KEA1-97 apoptosis inducer in breast cancer cells,KEA1-97 chemical for SCID mice tumor study,KEA1-97 compound for lysine 72 thioredoxin studies,KEA1-97 for biological assays,KEA1-97 for in vitro apoptosis assays,KEA1-97 in 5 mg/kg dosage for animal studies,KEA1-97 interaction disruptor for thioredoxin research,KEA1-97 small molecule for cancer research,KEA1-97 targeted therapy for cancer treatment,KEA1-97,lab-grade KEA1-97 for apoptosis studies,research-grade KEA1-97 for caspase 3 inhibition |
| storage temp. | 2-8°C |
| SMILES string | FC1=CC=C(C2=CC=C(NC3=NC(Cl)=NC(Cl)=N3)C=C2)C=C1 |
| InChI | 1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22) |
| InChI key | DUROVTLUQOYUPH-UHFFFAOYSA-N |
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¥ 2013.69
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¥ 3290.05
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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