纳曲酮的甲醇溶液盐酸盐，250MG，N3136-250MG，Sigma

销售价： ¥ 1858.38 / 件

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订货号： 0BR2424

品牌型号： Sigma N3136-250MG

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

Application

Naltrexone hydrochloride has been used:

as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

技术参数 Specifications

form	powder
Quality Segment	100
originator	Novartis
storage temp.	2-8°C
SMILES string	Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
InChI	1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
InChI key	RHBRMCOKKKZVRY-ITLPAZOVSA-N
Gene Information	human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)