- 商品介绍
- 规格参数
- 包装参数
Application
GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.
Biochem/physiol Actions
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
Preparation Note
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
| biological source | synthetic |
| Quality Segment | 100 |
| assay | ≥90% (HPLC) |
| solubility | DMSO: soluble (~1 mg/ml) |
| storage temp. | 2-8°C |
| SMILES string | CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 |
| InChI | 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChI key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
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¥ 2707.32
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¥ 5725.45
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¥ 2151.46
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¥ 2882.02
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¥ 2307.00
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¥ 1156.91
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¥ 745.60
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¥ 3852.13
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