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- 规格参数
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Biochem/physiol Actions
In vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1)
Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl |
| InChI | 1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3 |
| InChI key | NMHVAHHYKGXBMY-UHFFFAOYSA-N |
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¥ 12156.68
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¥ 4164.19
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