- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Application
Chlorpromazine hydrochloride has been used:
- as an antagonists for calmodulin kinase
- as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
- as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells
在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
Biochem/physiol Actions
吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。
氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
技术参数
Specifications
| Quality Segment | 200 |
| assay | ≥98% (TLC) |
| form | powder |
| mp | 194-196 °C |
| solubility | water: 50 mg/mL |
| web metadata keyword.default | CPZ; ; phenothiazine; 2D6; dopamine antagonist; dopamine receptor antagonist; cytotoxic; antiproliferative; nitrous oxide synthase inhibitor |
| originator | GlaxoSmithKline |
| SMILES string | Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 |
| InChI | 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H |
| InChI key | FBSMERQALIEGJT-UHFFFAOYSA-N |
| Gene Information | human ... DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR2A(3356) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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