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Biochem/physiol Actions
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker.
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | oil |
| color | pale yellow |
| solubility | DMSO: >5 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1 |
| InChI | 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3 |
| InChI key | VREPWWBWXVLSEF-UHFFFAOYSA-N |
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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