- 商品介绍
- 规格参数
- 包装参数
Application
Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| storage condition | desiccated |
| solubility | acetonitrile: water: ~1 mg/mL (60/40) |
| originator | AstraZeneca |
| storage temp. | 2-8°C |
| SMILES string | Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 |
| InChI | 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H |
| InChI key | SARMGXPVOFNNNG-UHFFFAOYSA-N |
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