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Biochem/physiol Actions
JH-II-127 is an orally available, brain penetrant, potent and selective inhibitor of both wild-type and G2019S mutant Leucine-rich repeat kinase 2 (LRRK2). JH-II-127 inhibits phosphorylation of the Ser910 and Ser935 of both wild-type and G2019S mutant LRRK2. It causes complete inhibition of LRRK2 in mouse brain at 100 mg/kg.
orally available, brain penetrant, potent and selective inhibitor of both wild-type and G2019S mutant Leucine-rich repeat kinase 2 (LRRK2)
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | Clc1c2c(nc([nH]c2NC)Nc3c(cc(cc3)C(=O)N4CCOCC4)OC)nc1 |
| InChI | 1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25) |
| InChI key | HUEKBQXFNHWTQQ-UHFFFAOYSA-N |
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