- 商品介绍
- 规格参数
- 包装参数
Application
SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.
Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.
G-quadruplex stabilizer; induces authophagy in cancer cells.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | yellow |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13 |
| InChI | 1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22) |
| InChI key | CTDCVGDSVHUYMA-UHFFFAOYSA-N |
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