- 商品介绍
- 规格参数
- 包装参数
Application
Vinblastine sulfate salt has been used:
- as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase
- as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line
- as an antimicrotubule agent in sub perineural glia of Drosophila brain
Biochem/physiol Actions
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 200 |
| assay | 96-102% (HPLC) |
| form | powder |
| color | white to light yellow |
| mp | 267 °C (dec.) (lit.) |
| antibiotic activity spectrum | neoplastics |
| mode of action | DNA synthesis | interferes |
| storage temp. | 2-8°C |
| SMILES string | OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2 |
| InChI | 1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1 |
| InChI key | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
| Gene Information | human ... TBCC(6903), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
询价
-
询价
-
¥ 1956.41
-
¥ 9737.84
-
询价
-
¥ 1509.00
-
¥ 2452.91
-
¥ 3476.87
-
¥ 2288.54
-
¥ 5426.00
-
¥ 26846.31
-
询价
-
¥ 58855.47
-
¥ 65710.50
-
询价
-
¥ 1799.83
-
询价
-
询价
微信小程序
7X24小时在线咨询