首页> 化学试剂> 其他化学试剂> 其他> Staurosporine from Streptomyces sp.，0.5MG，S4400-.5MG，Sigma

收藏产品

Staurosporine from Streptomyces sp.，0.5MG，S4400-.5MG，Sigma

销售价： ¥ 7981.62 / 件

在线询价

优惠：请询价

订货号： 0BS3836

品牌型号： Sigma S4400-.5MG

货期：询货期

最小订货量： 1件

+ -

加入购物车

联系我们

400-920-3909

微信扫一扫，手机采购

精选商品

ITS液体培养基补充剂（100x），I3146-5ML，Sigma

销售价： ¥ 706.75

加入购物车

LookOut DNA Erase，250 mL，L8917-250ML

销售价： ¥ 670.73

加入购物车

F-12培养基,N4888-6X500ML,Sigma

销售价： ¥ 2367.14

加入购物车

潮霉素B，20ML，10843555001，Roche

销售价： ¥ 2550.13

加入购物车

NADPH，1G，10621706001，Roche

销售价： ¥ 27460.69

加入购物车

光溜海绵素C，10UG，X2628-10UG，Sigma

销售价： ¥ 4893.32

加入购物车

商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

Chemical structure: indol derivative
Staurosporinefrom Streptomyces sp. is an alkaloid that induces apoptosis in a rangeof cell lines. It facilitates the inhibition of tumor cell proliferation, PKCinhibition, and blockage of cell cycle progression in various cells. Themechanisms followed by staurosporine-induced apoptosis differ among differentcell lines that include, mitochondrial apoptotic pathway, Bcl-2 overexpession,and caspase-independent mechanisms. It partially reverses multi-drug resistance (MDR), sensitizing cellswith MDR phenotype to cytotoxic agents. Staurosporine inhibits p-glycoprotein(Pgp) phosphorylation. However, the functional significance of Pgpphosphorylation is ill-defined.

Application

Staurosporine from Streptomyces sp. was used to induce cell death in human mesenchymal stem cells and to induce cell death by PKC inhibition in hamster lung fibroblast line CCL-39.

Biochem/physiol Actions

Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Staurosporine from Streptomyces sp. yields clear, colorless to faint yellow solution in methanol at 2 mg/ml.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the CDKs and InsR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

技术参数 Specifications

biological source	Streptomyces sp.
Quality Segment	300
assay	≥98% (HPLC)
form	film
mp	288-291 °C
solubility	DMSO: soluble,H₂O: insoluble,ethanol: soluble,methanol: soluble
antibiotic activity spectrum	neoplastics
mode of action	enzyme \| inhibits
storage temp.	2-8°C
SMILES string	CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI	1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
InChI key	HKSZLNNOFSGOKW-ZGQXJOJZSA-N

长度(mm)
宽度(mm)
高度(mm)
重量(kg)