CDDO-Im，5MG，SML3452-5MG，Sigma

Biochem/physiol Actions

Bifunctional CDDO analog that enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming KEAP1 and GSTP covalent adducts.
CDDO-Im is a bifunctional CDDO analog that enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteines, acyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Me, but also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures, 2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats).