VHL human，5UG，SRP2084-5UG，Sigma

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订货号： 0BS5269

品牌型号： Sigma SRP2084-5UG

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最小订货量： 1件

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产品介绍 Product Description

Biochem/physiol Actions

The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a.
von Hippel-Lindau (VHL) disease is a hereditary cancer with a predilection for the central nervous system and retina. The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a. VHL protein binds to elongin B, elongin C, and Cul2 to form a stable complex that targets hypoxia inducible factors (HIFs) for degradation and transcriptional regulation. In addition, VHL protein has also been shown to interact with specific protein kinase C isoforms, histone deacetylases and HIF-1 inhibitor (HIF-1).

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

技术参数 Specifications

biological source	human
recombinant	expressed in insect cells
assay	≥70% (SDS-PAGE)
form	frozen liquid
mol wt	~26 kDa
packaging	pkg of 5 μg
storage condition	avoid repeated freeze/thaw cycles
concentration	650 μg/mL
color	clear colorless
NCBI accession no.	NM_000551
UniProt accession no.	P40337
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... VHL(7428)

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