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Biochem/physiol Actions
SLM6031434 is a selective sphingosine (Sph) kinase 2 (SK2, SphK2, SpK2) inhibitor (r/m SphK2 Ki = 400/500 nM, r/m SphK1 Ki >20 μM) that effectively downregulates cellular sphingosine 1-phosphate (S1P) level (47% S1P & 143% Sph of control in U937 post 2h 100 nM SLM6031434 treatment) and selectively reduces plasma S1P in Sphk1-/-, but not Sphk2-/- mice in vivo (5 mg/kg i.v.). In contrary to Sphk2-KO mice, SLM6031434 treatment enhances plasma S1P in wild-type mice and offers neuroprotective efficacy against ischemic stroke (2 mg/kg i.v. 2h prior to tMCAO).
Selective sphingosine kinase 2 (SK2, SphK2, SpK2) inhibitor with neuroprotective efficacy against ischemic stroke in vivo.
Disclaimer
Hygroscopic
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | water: ≥2 mg/mL |
| storage temp. | -10 to -25°C |
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¥ 1259.40
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¥ 9737.84
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¥ 3152.47
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¥ 3812.28
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¥ 8982.64
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