N-Acetyltaurine,50MG,SML4286-50MG,Sigma

销售价: ¥ 1196.81 / 件
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订货号 0BS7676
品牌型号 Sigma SML4286-50MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Application

N-Acetyltaurine (NacT) may be used as a marker for ethanol intake using the HILIC-based liquid chromatography methods and mass spectrometry.


Biochem/physiol Actions

N-Acetyltaurine (NAT) is a taurine-derived metabolite regulated by PTER (N-acetyltaurine hydrolase), which catalyzes its hydrolysis to taurine and acetate. NAT can be produced through multiple pathways, including the reverse reaction of PTER, catalyzing taurine acetylation under high acetate conditions, non-enzymatic condensation of taurine with acetyl-CoA, and gut microbiome-mediated production, suggesting microbiota involvement in its regulation. N-Acetyltaurine suppresses appetite through the GFRAL receptor, mitigates inflammation, preserves blood–CSF barrier integrity, and reduces oxidative stress. Acetyltaurine also reduces neuroinflammation by limiting immune cell infiltration and lowering pro-inflammatory cells like neutrophils and macrophages. In vivo studies show it reduces food intake, body weight, and adiposity, while improving glucose tolerance, supporting overall metabolic health.


技术参数 Specifications
Quality Segment100
assay≥95% (HPLC)
formpowder
color white to beige
solubilityH2O: 2 mg/mL, clear
storage temp.2-8°C
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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