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产品介绍
Product Description
Biochem/physiol Actions
RQ-00203078 is an orally available potent and selective TRPM8 antagonist.
RQ-00203078 is an orally available potent and selective TRPM8 antagonist that potently reduces cation currents induced by menthol and other TRPM8 agonists. RQ-00203078 inhibits HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | ClC1=CC(C(F)(F)F)=CN=C1N(S(C2=CC=C(C(O)=O)C=C2)(=O)=O)CC3=CC=C(OC(F)(F)F)C=C3 |
| InChI | 1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) |
| InChI key | IJGQFZYYEHCCIZ-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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