Anti-MELK Antibody, clone 4F10X4, Rabbit Monoclonal，100UL，SAB5702341-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MELK (Q14680).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
material	colorless
clone	4F10X4, monoclonal
form	liquid
mol wt	75 kDa
species reactivity	rat, human
concentration	0.55 mg/mL
technique(s)	western blot: 1:500 - 1:2000
color	colorless
isotype	IgG
immunogen sequence	MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIIS
UniProt accession no.	Q14680
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MELK(9833)

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