- 商品介绍
- 规格参数
- 包装参数
Application
GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.
Biochem/physiol Actions
GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.
GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells.
GMX1778 is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | Clc1ccc(cc1)OCCCCCCN\C(=N\C#N)\Nc2ccncc2 |
| InChI | 1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25) |
| InChI key | BOIPLTNGIAPDBY-UHFFFAOYSA-N |
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