- 商品介绍
- 规格参数
- 包装参数
Application
SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development.
Biochem/physiol Actions
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to light tan |
| solubility | DMSO: soluble >10 mg/mL,H2O: insoluble |
| compatibility | for use with ABI 7700 |
| storage temp. | −20°C |
| SMILES string | Cc1nc2c(OCc3ccccc3)cccn2c1CC#N |
| InChI | 1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3 |
| InChI key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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¥ 15537.49
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