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Biochem/physiol Actions
PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to brown |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | room temp |
| SMILES string | CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl |
| InChI | 1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3 |
| InChI key | AZEXWHKOMMASPA-UHFFFAOYSA-N |
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¥ 2013.69
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¥ 1779.22
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¥ 5725.45
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¥ 1196.00
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¥ 1586.69
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¥ 2406.69
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¥ 3896.11
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¥ 5804.96
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¥ 2288.54
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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