- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
LFM-A13 is a potent and selective inhibitor of Bruton′s tyrosine kinase (BTK)
LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥19 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | C\C(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br |
| InChI | 1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6- |
| InChI key | UVSVTDVJQAJIFG-VURMDHGXSA-N |
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¥ 2622.09
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¥ 2814.26
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¥ 2013.69
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¥ 2019.57
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¥ 4173.75
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¥ 5887.85
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¥ 3290.05
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¥ 3812.28
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无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 3684.34
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