- 商品介绍
- 规格参数
- 包装参数
General description
A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.
Biochem/physiol Actions
Primary Target
5-HT uptake transporter
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.
Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| assay | ≥99% (HPLC) |
| Quality Segment | 100 |
| form | solid |
| potency | 3.3 nM Ki |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 100 mM,ethanol: 50 mM |
| storage temp. | 2-8°C |
| SMILES string | [Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl |
| InChI | 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1 |
| InChI key | BLFQGGGGFNSJKA-XHXSRVRCSA-N |
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¥ 1148.92
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¥ 1779.22
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¥ 1866.29
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¥ 9737.84
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