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产品介绍
Product Description
Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | DMSO: >20 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O |
| InChI | 1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3 |
| InChI key | LAKWINYVWJPHQW-UHFFFAOYSA-N |
| 长度(mm) | |
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