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Biochem/physiol Actions
Cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293)
Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1 |
| InChI | 1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2 |
| InChI key | JDVOIBFEFVKUPL-UHFFFAOYSA-N |
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¥ 2290.21
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¥ 1259.40
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¥ 1563.36
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¥ 1451.54
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¥ 2068.25
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¥ 4173.75
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¥ 3152.47
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¥ 5990.26
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