- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Biochem/physiol Actions
JB170 is a highly specific AURORA-A degrader (PROTAC) comprising aurora kinase inhibitor alisertib connected to the CEREBLON-binding molecule thalidomide. JB170 induces rapid and durable degradation of AURORA-A in cancer cells leading to strong S-phase arrest and apoptosis.
highly specific AURORA-A degrader (PROTAC) that induces rapid and durable degradation of AURORA-A in cancer cells
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | O=C1N(C2CCC(NC2=O)=O)C(C3=C1C(OCC(NCCOCCOCCNC(C4=CC=C(NC5=NC(C(C=CC(Cl)=C6)=C6C(C7=C(OC)C=CC=C7F)=NC8)=C8C=N5)C=C4OC)=O)=O)=CC=C3)=O |
| InChI key | GYKNPXCQINZRLL-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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