- 商品介绍
- 规格参数
- 包装参数
General description
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 32-48 nmol/min·mg |
| mol wt | ~89 kDa |
| NCBI accession no. | NM_005228 |
| application(s) | cell analysis |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... EGFR(1956) |
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¥ 1148.92
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¥ 4968.78
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¥ 4897.21
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¥ 2151.46
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¥ 2268.97
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¥ 1476.00
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¥ 1301.36
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¥ 4020.77
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¥ 1476.40
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¥ 1351.48
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¥ 3476.87
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