DRP1 Inhibitor, MIDI，5MG，SML3989-5MG，Sigma

Biochem/physiol Actions

Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.



DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.