AMPK (α1/β1/γ3), active, His tagged human,10UG,A4486-10UG,Sigma

销售价: ¥ 14728.60 / 件
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订货号 0BU8173
品牌型号 Sigma A4486-10UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Biochem/physiol Actions

AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an α catalytic subunit, and non-catalytic β and γ subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism.


Physical form

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.


Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany


技术参数 Specifications
recombinantexpressed in baculovirus infected Sf9 cells
Quality Segment200
product linePRECISIO® Kinase
assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
specific activity157-213 nmol/min·mg
mol wtA1 subunit ~68 kDa,B1 subunit ~38 kDa,G3 subunit ~51 kDa
UniProt accession no.Q13131,Q9UGI9,Q9Y478
shipped indry ice
storage temp.−70°C
Gene Informationhuman ... PRKAA1(5562), PRKAB1(5564), PRKAG3(53632)
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