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General description
The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K+ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K+ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.
Immunogen
synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat KV11.3.
Biochem/physiol Actions
The KV11.3 antibody is directed against an intracellular epitope of C-terminal part of KV11.3.
The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K+ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K+ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.
Physical form
Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.
Preparation Note
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| species reactivity | mouse, human, rat |
| technique(s) | immunohistochemistry: suitable using rat brain sections,western blot: 1:300 using rat brain lysates |
| UniProt accession no. | Q9NS40 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... KCNH7(90134) mouse ... Kcnh7(170738) rat ... Kcnh7(170739) |
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