- 商品介绍
- 规格参数
- 包装参数
General description
Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.
Application
Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.
Biochem/physiol Actions
Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.
Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D +15 to +25°, c = 1 in methanol |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 5 mg/mL (clear solution; warmed) |
| storage temp. | room temp |
| SMILES string | OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 |
| InChI | 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1 |
| InChI key | PMGQWSIVQFOFOQ-YKVZVUFRSA-N |
| Gene Information | human ... HRH1(3269) |
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