- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
S 26948 belongs to the non-thiazolidinedione (TZD) class of drugs. It has the potential to treat diabetes and atherogenesis.
S 26948 is a partial PPARγ agonist; selective PPARγ modulator (SPPARγM).
S 26948 is a selective PPARγ modulator (SPPARγM). S 26948 is as effective as rosiglitazone in reducing insulin resistance and lipid homeostasis, but does not increase body or white adipose tissue weight. S 26948 also leads to different co-activatior recruitment to PPARγ than rosiglitazone.
Features and Benefits
This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 10 mg/mL (clear solution) |
| storage temp. | 2-8°C |
| SMILES string | COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC |
| InChI | 1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3 |
| InChI key | NSMJEHGOMXSLCW-UHFFFAOYSA-N |
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