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Mitochondrial Pyruvate Carrier Inhibitor, UK5099，5MG，5048170001，Sigma

销售价： ¥ 1503.67 / 件

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订货号： 0BV3394

品牌型号： Sigma 5048170001

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC₅₀ = 50 nM in rat heart mitochondria; K_i ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
mitochondria
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
Use only fresh DMSO for reconstitution.

Other Notes

Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA110, 5422.
Bricker, D.K., et al. 2012. Science337, 96.
Herzig, S., et al. 2012. Science337, 93.
Hinoi, E., et al. 2006. Mol. Pharmacol.70, 925.
Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta1707, 221.
Halestrap, A.P. 1978. Biochem. J.172, 377.
Halestrap, A.P. 1975. Biochem. J.145, 85.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

assay	≥99% (HPLC)
Quality Level	100
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
color	bright yellow
solubility	DMSO: 100 mg/mL
storage temp.	2-8°C
SMILES string	[n]2(c3c(c(c2)\C=C(\C(=O)O)/C#N)cccc3)c1ccccc1
InChI	1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI key	BIZNHCWFGNKBBZ-JLHYYAGUSA-N

长度(mm)
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