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General description
A cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
Packaging
Packaged under inert gas
Other Notes
Chau, N.M., et al. 2005. Cancer Res.65, 4918.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥90% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | brown |
| solubility | DMSO: 50 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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¥ 1302.89
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¥ 3290.05
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¥ 8982.64
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¥ 20380.83
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¥ 2666.57
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¥ 3404.94
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¥ 1351.48
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¥ 2754.43
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¥ 8072.66
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¥ 65710.50
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¥ 55311.07
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