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General description
Akt磷酸化及其体外激酶活性（完全抑制<5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039 ）的细胞可渗透性、可逆性和选择性抑制剂。
Biochem/physiol Actions
主靶
Akt
二级靶标
Rn细胞系（IC₅₀ = 2-5 µM）
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：<5 µM 抗Akt；2-5 µM 抗Rh（横纹肌肉瘤）细胞系生长
Packaging
用惰性气体包装
Preparation Note
在复溶后分装并冻存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Tsvetkov, A.S., et al. 2010.Proc.Natl.Acad.Sci. USAin press.
Thimmaiah, K.N., et al. 2005.J. Biol. Chem.280, 31924.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | white |
| solubility | water: 1 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [Cl-].Clc1cc2c(cc1)Oc3c(cccc3)N2CCCC[N+H](CC)CC |
| InChI | 1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H |
| InChI key | SVKSJUIYYCQZEC-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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