- 商品介绍
- 规格参数
- 包装参数
General description
An antitumor agent of microbial origin that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Epoxomicin also displays potent anti-inflammatory activity in vivo.
An antitumor and anti-inflammatory agent that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidyl-glutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Does not affect the activities of non-proteasomal proteases such as trypsin, cathepsin B, or chymotrypsin. A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324801) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: no
Primary Target
CT-L,T-L,PGPH activity of proteasome
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Meng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403.
Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283.
Hanada, M., et al. 1992. J. Antibiot. 45, 1746.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 1 mg/mL,methanol: 1 mg/mL |
| web metadata keyword.default | Epoxomicin 1mg vial,Epoxomicin 5mg research chemical,Epoxomicin CAS number 187250-75-0,Epoxomicin and proteasome inhibition studies,Epoxomicin anti-inflammatory agent,Epoxomicin chymotrypsin-like inhibitor,Epoxomicin for cell culture applications,Epoxomicin for proteasome activity assays,Epoxomicin laboratory grade,Epoxomicin synthetic proteasome inhibitor XIV,Epoxomicin synthetic proteasome inhibitor,Epoxomicin,Sigma-Aldrich Epoxomicin for research,high purity Epoxomicin proteasome inhibitor |
| shipped in | ambient |
| storage temp. | −20°C |
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