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General description
A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | orange |
| solubility | DMSO: 100 mg/mL, clear, red |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O |
| InChI | 1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2 |
| InChI key | MAASHDQFQDDECQ-UHFFFAOYSA-N |
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