首页> 化学试剂> 其他化学试剂> 其他> AG 1295，5MG，658550-5MGCN，Sigma

收藏产品

AG 1295，5MG，658550-5MGCN，Sigma

销售价： ¥ 1594.84 / 件

在线询价

优惠：请询价

订货号： 0BV5767

品牌型号： Sigma 658550-5MGCN

货期：询货期

最小订货量： 1件

+ -

加入购物车

联系我们

400-920-3909

微信扫一扫，手机采购

精选商品

ITS液体培养基补充剂（100x），I3146-5ML，Sigma

销售价： ¥ 706.75

加入购物车

LookOut DNA Erase，250 mL，L8917-250ML

销售价： ¥ 670.73

加入购物车

F-12培养基,N4888-6X500ML,Sigma

销售价： ¥ 2367.14

加入购物车

潮霉素B，20ML，10843555001，Roche

销售价： ¥ 2550.13

加入购物车

NADPH，1G，10621706001，Roche

销售价： ¥ 27460.69

加入购物车

光溜海绵素C，10UG，X2628-10UG，Sigma

销售价： ¥ 4893.32

加入购物车

商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor (PDGF) receptor kinase (IC₅₀ = 500 nM) and PDGF-dependent DNA synthesis (IC₅₀ = 2.5 µM) in Swiss/3T3 cells. Has no effect on EGF receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis. A potent blocker of smooth muscle cell proliferation.
Selectively inhibits platelet-derived growth factor (PDGF) receptor kinase (IC₅₀ = 500 nM) and the PDGF-dependent DNA synthesis (IC₅₀ = 2.5 µM) in Swiss 3T3 cells. Has no effect on epidermal growth factor (EGF) receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PDGFR kinase
Product competes with ATP.
Reversible: yes
Target IC₅₀: 500 nM against PDGFR kinase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Banai, S., et al. 1998. Circulation 97, 1960.
Levitzki, A., and Gazit, A. 1995. Science267, 1782.
Kovalenko, M., et al. 1994. Cancer Res.54, 6106.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Segment	100
assay	≥95% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
color	white
solubility	DMSO: 10 mg/mL,dichloromethane: soluble
shipped in	ambient
storage temp.	−20°C
SMILES string	n1c2c(ncc1c3ccccc3)cc(c(c2)C)C
InChI	1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
InChI key	FQNCLVJEQCJWSU-UHFFFAOYSA-N

长度(mm)
宽度(mm)
高度(mm)
重量(kg)