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General description
Forkhead box protein K2 (UniProt: Q01167; also known as Cellular transcription factor ILF-1, FOXK1, Interleukin enhancer-binding factor 1) is encoded by the FOXK2 (also known as ILF, ILF1) gene (Gene ID: 3607) in human. Forkhead box protein K2 is a transcriptional regulator that recognizes the core sequence 5′-TAAACA-3′. It is expressed in both lymphoid and non-lymphoid cells. Three isoforms of Forkhead box protein K2 have been reported that are produced by alternative splicing. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Forkhead box protein K2 is reported to positively regulate WNT/beta-catenin signaling by translocating DVL proteins into the nucleus. Higher levels of FOXK1 and FOXK2 are reported in human colorectal cancers and correlate with DVL nuclear localization. Both FOXK1 and FOXK2 proteins are shown to act as transcriptional repressors of autophagy in muscle cells and fibroblasts. They specifically recruit Sin3A HDAC complexes to restrict acetylation of histone H4 and expression of critical autophagy genes. The loss of FOXK1 and FOXK2 proteins results in the upregulation of several genes controlling the initiation and nucleation of autophagosome formation. (Ref.: Bowman, CJ., et al. (2014). Nat. Cell Biol. 16(12); 1202-1214).
~69 kDa observed; 69.06 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to 17 amino acids from the C-terminal half of human Forkhead box protein K2.
Application
Anti-Forkhead box protein K2 (FOXK2), Cat. No. ABE1323, is a highly specific rabbit polyclonal antibody that targets Forkhead box protein K2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Research Category
Epigenetics & Nuclear Function
Western Blotting Analysis: 2 µg/mL from a representative lot detected Forkhead box protein K2 (FOXK2) in HeLa cell lysate.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Forkhead box protein K2 (FOXK2) in human cerebral cortex, human prostate cancer, and human pancreatic cancer tissues.
Biochem/physiol Actions
This rabbit polyclonal antibody detects Forkhead box protein K2 in human cells. It targets an epitope within 17 amino acids from the C-terminal half.
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Forkhead box protein K2 (FOXK2) in HEK293 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| isotype | IgG |
| NCBI accession no. | NP_004505.2 |
| UniProt accession no. | Q01167 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | human ... FOXK2(3607) |
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