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General description
A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 µM).
Packaging
Packaged under inert gas
Other Notes
Vincent, F., et al. 2009. Biochem. Biophys. Res. Commun.389, 490.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | DMSO: 50 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [S](=O)(=O)(N(C(C)C)CCNC(C)C)c1c(cc(cc1)Cl)Cl |
| InChI | 1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3 |
| InChI key | IHYZMEAZAIFMTN-UHFFFAOYSA-N |
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¥ 12156.68
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¥ 2528.88
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¥ 9737.84
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