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General description
Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1; UniProt Q15418; also known as 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1) is encoded by the RPS6KA1 (also known as MAPKAPK1A, RSK1) gene (Gene ID 6195) in human. Ribosomal s6 kinases (RSKs) are serine/threonine kinases that play a role in mediating Mek1/2-Erk1/2 mitogen-activated protein (MAP) kinase pathway signaling events. There exist two types of RSKs, p70rsk (a.k.a. S6 Kinase or S6-H1 kinase) and p90rsk (a.k.a. MAPK-activated protein kinase). Six p90rsk-coding genes have been identified in human, RPS6KA1 (MAPKAPK1A, RSK1), RPS6KA2 (MAPKAPK1C, RSK3), RPS6KA3 (MAPKAPK1B, RSK2), RPS6KA4 (MSK2), RPS6KA5 (MSK1), and RPS6KA6 (RSK4). p90RSK1 is activated by sequential phosphorylation events, where it is first phosphorylated by Erk1/2 on the C-terminal kinase domain (CTKD) Thr573, leading to subsequent Ser380 phosphorylation in the N-terminal AGC kinase-type domain. Alternatively, Ser380 can be phosphorylated directly by MK2/3 independent of CTKD Thr573 phosphorylation.
~85 kDa observed. 82.88 kDa (rat), 86.47 kDa (mouse), 82.72 kDa (human isoform 1), 83.93 kDa (human isoform 2), 72.70 kDa (human isoform 3), and 81.15 kDa (human isoform 4) calculated. Uncharacterized band(s) may appear in some lysates.
Immunogen
Epitope: Linker region between two kinase domains.
KLH-conjugated linear peptide corresponding to a sequence from the linker region between the two human Rsk1 kinase domains.
Application
Anti-Rsk1 Antibody, clone 3G5.1 is an antibody against Rsk1 for use in Western Blotting.
Biochem/physiol Actions
Clone 3G5.1 target epitope sequence is present in all four human Rsk1 spliced isoforms reported by UniProt (Q15418).
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in PC12 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rsk1 in 10 µg of PC12 rat pheochromocytoma cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 3G5.1, monoclonal |
| species reactivity | rat |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), Xenopus (based on 100% sequence homology), human (based on 100% sequence homology), porcine (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_002944 |
| UniProt accession no. | Q15418 |
| target post-translational modification | unmodified |
| Gene Information | human ... RPS6KA1(6195) |
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