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General description
Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50<10 µM), and PLA2.
Biochem/physiol Actions
Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Product does not compete with ATP.
Target IC50: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
| Quality Level | 100 |
| description | Merck USA index - 14, 2185 |
| assay | ≥99% (HPLC) |
| form | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | off-white |
| solubility | methanol: 10 mg/mL,water: 50 mg/mL |
| anion traces | sulfate (SO42-): ≤0.05% |
| cation traces | Fe: ≤0.001%,heavy metals: ≤0.002% |
| shipped in | ambient |
| storage temp. | 10-30°C |
| SMILES string | S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-] |
| InChI | 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H |
| InChI key | FBSMERQALIEGJT-UHFFFAOYSA-N |
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