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General description
A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Su, J.C., et al. 2009, Life Sci.85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | brown |
| solubility | DMSO: 50 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| 长度(mm) | |
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¥ 1259.40
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¥ 5725.45
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¥ 6330.00
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¥ 4404.38
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¥ 1301.36
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¥ 5014.59
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¥ 4020.77
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¥ 2132.12
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¥ 9909.51
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¥ 15537.49
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¥ 29754.56
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¥ 42661.77
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