- 商品介绍
- 规格参数
- 包装参数
General description
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Biochem/physiol Actions
Primary Target
RAGE
Reversible: yes
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-ELKVLMEKEL-NH2
Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 200 |
| assay | ≥95% (HPLC) |
| form | powder |
| potency | 2 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | water: 5 mg/mL |
| shipped in | dry ice |
| storage temp. | −20°C |
| 长度(mm) | |
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¥ 1148.92
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¥ 1866.29
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¥ 9207.92
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¥ 5887.85
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¥ 2882.02
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¥ 5014.59
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¥ 5061.38
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¥ 1586.69
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