- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p53 interaction with Bcl-xL and Bcl-2 proteins
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Leu, J., et al. 2009. Mol. Cell36, 15.
Strom, E., et al. 2006. Nat. Chem. Biol.2, 474.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | off-white |
| solubility | DMSO: 50 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [S](=O)(=O)(N)C#Cc1ccccc1 |
| InChI | 1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11) |
| InChI key | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
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¥ 2707.32
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¥ 4164.19
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¥ 2814.26
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¥ 1259.40
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¥ 1302.89
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¥ 1779.22
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¥ 2068.25
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¥ 4173.75
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¥ 6894.69
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¥ 5167.58
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