![2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide，100MG，D0815-100MG，Sigma](http://static.bingosci.com/uploadfile/opc/editor/file/202608/05/1785897194512525_M.png)
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General description
一种有效的细胞渗透性钙蛋白酶I和II抑制剂（Ki = 8 nM），还可减少培养的背根神经节中辣椒素介导的细胞死亡。据报道，它可以阻止A23187诱导的离体海马锥体神经元神经突生长的抑制。对谷氨酸诱导的毒性表现出神经保护作用。
Biochem/physiol Actions
主要靶标
钙蛋白酶1，钙蛋白酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定1个月。
Other Notes
Chatterjee, S., et al. 1998.J. Med. Chem.41, 2663.
Rami, A., et al. 1997.Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997.Biochemistry36, 8377.
Klafki, H., et al. 1996.J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995.Neuroscience 65, 1099.
Song, D.K., et al. 1994.J. Neurosci. Res. 39, 474.
Z-Val-Phe-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | lyophilized solid |
| potency | 8 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | white |
| solubility | DMSO: 20 mg/mL (Use only anhydrous DMSO.) |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | N([C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O)C(=O)OCc1ccccc1 |
| InChI | 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1 |
| InChI key | NGBKFLTYGSREKK-PMACEKPBSA-N |
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