4-Hydroxyphenylretinamide,5MG,390900-5MGCN,Sigma

销售价: ¥ 1826.76 / 件
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订货号 0BW1904
品牌型号 Sigma 390900-5MGCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.


Biochem/physiol Actions

Cell permeable: no
Primary Target
Active in the prevention and treatment of a variety of neoplasms in animals.
Product does not compete with ATP.
Reversible: no


Packaging

Packaged under inert gas


Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


Other Notes

Formelli, F., et al. 1996. FASEB J. 10, 1014.
Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
Delia, D., et al. 1993. Cancer Res. 53, 6036.
Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
McCarthy, D.J., et al. 1987. Cancer Res.47, 5014.
Moon, R.C., et al. 1979. Cancer Res.39, 1339.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)


技术参数 Specifications
Quality Level100
descriptionMerck USA index - 14, 3998
assay≥97% (TLC)
formsolid
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze,protect from light
color orange
solubilityDMSO: 25 mg/mL,acetone: soluble,ethanol: soluble
shipped inambient
storage temp.−20°C
SMILES stringN(c2ccc(cc2)O)C(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(CCCC1(C)C)C
InChI1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI keyAKJHMTWEGVYYSE-FXILSDISSA-N
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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