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General description
ATPase H+ transporting accessory protein 1 (ATP6AP1) is an accessory subunit of the V-ATPase. This gene is located on human chromosome Xq28. ATP6AP1 is also referred as Ac45. It is abundantly expressed a high levels in neuronal and (neuro-) endocrine cells and osteoclasts.
Immunogen
synthetic peptide corresponding to amino acids 451-465 of human ATP6AP1
Application
Rabbit anti-ATP6AP1 (451-465) antibody can be used for western blot (1:500-1:2,000) assays.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
ATPase H+ transporting accessory protein 1 (ATP6AP1) is known to cause an X-linked N-glycosylation syndrome with liver disease. It is essential for endosomal acidification. It also participates in membrane trafficking and Ca2+-dependent membrane fusion.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | PBS solution |
| mol wt | antigen ~52 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:2,000 |
| UniProt accession no. | Q15904 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... ATP6AP1(537) |
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