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Monoclonal Anti-TNRC6C antibody produced in mouse，100UG，SAB1403333-100UG，Sigma

销售价： ¥ 4046.38 / 件

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订货号： 0BL2312

品牌型号： Sigma SAB1403333-100UG

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

Mouse monoclonal antibody raised against a partial recombinant TNRC6C.
TNRC6C (Trinucleotide repeat containing 6C) is a member of GW182 (Gly-Trp) family consisting of a domain similar to Drosophila GW182 (also known as Gawky), a domain rich in GW or WG repeats followed by a glutamine (Q)-rich region at the N-proximal end, a central ubiquitin-associated (UBA) domain and an RNA-binding domain termed as RRM.

Immunogen

TNRC6C (NP_061869, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
TDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAK

Application

Monoclonal Anti-TNRC6C antibody produced mouse is suitable for indirect ELISA.

Biochem/physiol Actions

TNRC6C (Trinucleotide repeat containing 6C) plays an important role in the microRNA repression during protein synthesis via miRNA pathway. The C-terminal RRM RNA-binding domain mediates the process of translational repression. Its GW-rich and Q-rich domain also suppress the expression for protein synthesis by binding to a reporter mRNA. In addition to translational repression, the members of the GW182 family, also participate in the deadenylation and decay of miRNA by interacting with argonaute proteins.

Physical form

Solution in phosphate buffered saline, pH 7.4

技术参数 Specifications

biological source	mouse
Quality Level	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	3G11, monoclonal
form	buffered aqueous solution
mol wt	antigen ~36.89 kDa
species reactivity	human
technique(s)	immunofluorescence: suitable,indirect ELISA: suitable
isotype	IgG2aκ
NCBI accession no.	NM_018996
UniProt accession no.	Q9HCJ0
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... TNRC6C(57690)

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