- 商品介绍
- 规格参数
- 包装参数
General description
Both MIP-1α and MIP-1β (macrophage inflammatory proteins-1α and β) are structurally and functionally related CC chemokines. They are secreted by activated human monocytes and peripheral blood lymphocytes. The gene encoding this protein is localized on human chromosome 17q12. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1β is a 7.6kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Biochem/physiol Actions
MIP-1α and MIP-1β (macrophage inflammatory proteins-1α and β) participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and natural killer (NK) cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β (also known as C-C motif chemokine ligand 4) selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
| biological source | human |
| recombinant | expressed in E. coli |
| assay | ≥98% (HPLC),≥98% (SDS-PAGE) |
| form | lyophilized |
| mol wt | 7.6 kDa |
| packaging | pkg of 10 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities | <0.1 EU/μg endotoxin, tested |
| color | white to off-white |
| UniProt accession no. | P13236 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... CCL4(6351) |
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¥ 1148.92
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¥ 5887.85
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¥ 9737.84
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¥ 2573.97
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¥ 2617.87
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¥ 2307.00
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¥ 4020.77
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¥ 2869.87
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¥ 787.34
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¥ 1586.69
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