SRT3025 hydrochloride，10MG，SML3397-10MG，Sigma

Biochem/physiol Actions

SRT3025 is an orally active sirtuin 1 activator (Sirt1 EC1.5 ≤1 μM, Emax ≥150% and <300%) that reduces cellular acetylation of Sirt1 substrates FoxO1 (induced by RANKL ) and histone 3 (1-10 μM; murine bone marrow macrophages) and exhibits in vivo efficacy in a murine atherosclerosis model (3.18 g/kg high-cholesterol diet; mice) and ovariectomy-induced bone loss in female mice (50 & 100 mg/kg via daily p.o.).
Orally active sirtuin 1 (Sirt1) activator in cultures and in vivo.